Basic Info.
Model NO.
500activity 800 activity
Extraction Process
Chemical
Application
Health Care Products, Medicine
Extract Source
Leech Extract
Source
in The Leech and Its Salivary Glands
Category
Natural Specific Thrombin Inhibitors
Transport Package
Foil Wrapper
Product Description
Product Name The mechanism of hirudin action on thrombin edited report
A series of enzymatic cascades of amplifying reactions activate prothrombin to produce thrombin during endogenous and exogenous coagulation. Thrombin is a serine protease that plays a key role in thrombus formation, including cascade reaction, fibrin deposition and platelet activation during coagulation. Anticoagulant inhibitors can be divided into indirect thrombin inhibitors and direct antithrombin inhibitors. The former is anticoagulant by catalyzing natural inhibitors of thrombin (ATIII or heparin cofactor II). Hirudin is a specific thrombin inhibitor, which can directly bind to thrombin, and its anticoagulant effect does not depend on ATIII or heparin cofactor II, which is a direct thrombin inhibitor. Hirudin inactivates thrombin by acting on two sites, namely the inactive substrate recognition site and the enzyme active center, and binds to thrombin 1:1 to form irreversible complex, thus rendering thrombin ineffective. The anticoagulant activity of hirudin is not only specific, but also stronger than that of heparin. In addition, hirudin not only inhibits free thrombin in plasma.
Sample Display Product FunctionAnimal experiments and clinical studies have shown that hirudin is highly effective in anticoagulation, antithrombosis, and preventing thrombin catalyzed coagulation factor activation and platelet reaction, and other further blood stasis phenomena. In addition, it can inhibit thrombine-induced fibroblast proliferation and thrombine-induced endothelial cell stimulation. Compared with heparin, it not only takes less, does not cause bleeding, and does not depend on endogenous cofactors; Heparin, on the other hand, has a risk of causing bleeding. Antithrombin III is often reduced in the course of diffuse intravascular coagulation, which limits the efficacy of heparin. Leeches may be more effective.
Product Application Hirudin is a promising anticoagulant and blood stasis drug, which can be used in the treatment of various thrombotic diseases, especially the treatment of venous thrombosis and diffuse vascular coagulation. It can also be used to prevent the formation of arterial thrombosis after surgical operation, and to prevent the formation of thrombosis after thrombus dissolution or vascular reconstruction. Improve extracorporeal blood circulation and hemodialysis process. Hirudin can promote wound healing in microsurgery, which often fails due to anastomotic vascular embolism. Hirudin has also been shown to play a role in cancer treatment. It can stop the metastasis of tumor cells, and has been shown to be effective in tumors such as fibrosarcoma, osteosarcoma, angiosarcoma, melanoma and leukemia. Hirudin can also be used in combination with chemotherapy and radiotherapy to enhance efficacy by promoting blood flow in the tumor.
Our Company Baoji Runyu Bio-Technology Co., Ltd. is a high-tech enterprise specializing in the development, extraction,
processing of active ingredients from natural plant extracts and herbal extracts, as well as the production of
pharmaceutical intermediate, monomer and health care products.
Baoji Runyu Bio-Technology Co., Ltd. has a high-quality production, R&D, and management team with professionals
who are engaged in the plant biotechnology research and development for over 15 years. Our company attaches
importance to the product development, we not only develop new products by ourselves but also cooperate with
domestic famous factories, colleges and universities, and laboratories in the industry actively. In addition, our company
has a series of advanced production equipment such as the preparation, extraction, leaching, chromatography, concentration,
purification, and vacuum drying equipment of pure water, as well as high performance liquid chromatography (HPLC) and various
experimental analysis equipment. In order to ensure the quality of our delivery products, strict management procedure for production
is executed.
Our company's main products cover Huperzia Serrata Extract - Huperzine-A, Horse Chestnut Extract - Aescin, Polygonum Cuspidatum
Extract/Grape Skin Extract - Resveratrol, Butcher's Broom Extract - Ruscogenin, Phloretin, Okra Extract, Curcumin, Sinomenine Hydrochloride,
Berbamine Hydrochloride, Ginseng Extract - Ginsenoside, Evodiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcumin,
Xanthin, Zeaxanthin, Ursolic acid, Naringin and Neohesperidin series products, Luteolin, Nattokinase, Piperine, Paeoniflorin, Pjosphatidylserine.
Most of our products are sold to inland, Macao and Taiwan, Europe and America, Southeast Asia and other countries and regions, enjoy high
popularity in these places and become the preferred products of many pharmaceutical, food, health care products and cosmetics production
enterprises at home and abroad.
Packing and ShippingDelivery time :Within 3~10 working days after receiving the confirmed payment
MOQ : 1KG
Net Weight : 25kgs/Drum
Gross Weight : 28kgs/Drum
Payment :T/T,paypal or Alibaba Payment,If you need other payment methods, please contact us.
Freight : The freight cost will charge according to the destination detailed quantity.
Storage : Stored in dry and cool place, keep away from strong light and heat.
Shelf Life :Two years when properly stored.
OUR SERVICE 1. We inspect the manufacture process strictly and the quality can be controlled.
2. We supply high quality products, reasonable price, prompt delivery.
3. Our products are natural,pure and no additives.
4. Free Sample To Test Quality First is Accepted.
5. Our products can be OEM,packaging can be done according to the yours requirements.
6. After SalServices 24*7.
FAQ:1.What's the min order for the usual?
15kg. As for the high-value products, min order starts from 1g or 10g.
2.What's the sample cost?
Free samples for normal products. Will charge on high-value products like huperzine-A.
3.What's the package and payment terms?
We pack with 2 layers of food-grade plastic bags inside and aluminum foil bag outside, 10-25kg/drum.And payment terms are normally T/T & Western Union.
4.What's the shipping time?
May take 3-5 working days to Asia or surrounding countries by EMS etc..
5~10 working days to European or Americ countries by EMS etc..
5.How do we do if the goods doesnt match with the sample?
Usually we'll confirm the testing method, if it is because of the quality, we''ll recalled the unquality goods and send free the products to you again. Please don't worry, our products were tested before the shipping.
Address:
a 2006, Yikongjian Huaxia, Gaoxin 5th Road, China. (721006), Baoji, Shaanxi, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals
Management System Certification:
ISO 9001
Company Introduction:
Baoji Runyu Bio-Technology Co., Ltd. Specialized in active ingredients from natural plant extracts and herbal extract, as well as in food additives, fruit powder and health care products more than 15 years in China.
We have long-term relationship with several Third-party Testing organizations to ensure high quality.
Our company′s main products cover Huperzia Serrata Extract - Huperzine-A, Horse Chestnut Extract - Aescin, Polygonum Cuspidatum Extract/Grape Skin Extract - Resveratrol, Butcher′s Broom Extract - Ruscogenin, Phloretin, Okra Extract, Curcumin, Sinomenine Hydrochloride, Berbamine Hydrochloride, Ginseng Extract - Ginsenoside, Evodiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcumin, Xanthin, Zeaxanthin, Ursolic acid, Naringin and Neohesperidin series products, Luteolin, Nattokinase, Piperine, Paeoniflorin, Pjosphatidylserine. Most of our products are sold to inland, Macao and Taiwan, Europe and America, Southeast Asia and other countries and regions, enjoy high popularity in these places and become the preferred products of food, health care products and cosmetics production enterprises at home and abroad.
With the concept of "Quality First, Customer Foremost, Sincere Management", we are devoting to build the quality brand. We are looking forward to communicating and cooperating with friends from all over the world. Let us work hand in hand to create a brilliant tomorrow.