Basic Info.
Application
Food, Health Care Products, Medicine
Extract Source
Camptotheca Acuminata Extract
Product Name
Camptothecin 98%
Product Description
Product Description Camptothecin (CPT) is a cytotoxic quino line alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
Sample Display
Product Parameter Product name: Camptothecin
CAS No. 7689-03-4
Molecular formula: C20H16N2O4
Molecular weight: 348.36
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf
Grade: Pharmaceutical and food
test report Items | Standards | Results |
Physical Analysis | | |
Description | Light Yellow Powder | Complies |
Assay | 98% | 98.2% |
Mesh Size | 100 % pass 80 mesh | Complies |
Ash | ≤ 5.0% | 2.85% |
Loss on Drying | ≤ 5.0% | 2.85% |
Chemical Analysis | | |
Heavy Metal | ≤ 10.0 mg/kg | Complies |
Pb | ≤ 2.0 mg/kg | Complies |
As | ≤ 1.0 mg/kg | Complies |
Hg | ≤ 0.1 mg/kg | Complies |
Microbiological Analysis | | |
Residue of Pesticide | Negative | Negative |
Total Plate Count | ≤ 1000cfu/g | Complies |
Yeast&Mold | ≤ 100cfu/g | Complies |
E.coil | Negative | Negative |
Salmonella | Negative | Negative |
Product Function:
1.Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by
stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor
cell death.
2.In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-
leukaemia activity.
Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding /
unwinding of the
supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of
DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin,
have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained
satisfying curative effects in clinic.
Application:
1.Camptothecin can make changes in skin epidermal keratinization process.
2.Camptothecin is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.
3.Camptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and
leukemia,with fewer side effects than camptothecine.
Our Company
Baoji Runyu Bio-Technology Co., Ltd. is a high-tech enterprise specializing in the development, extraction,
processing of active ingredients from natural plant extracts and herbal extracts, as well as the production of
pharmaceutical intermediate, monomer and health care products.
Baoji Runyu Bio-Technology Co., Ltd. has a high-quality production, R&D, and management team with professionals
who are engaged in the plant biotechnology research and development for over 15 years. Our company attaches
importance to the product development, we not only develop new products by ourselves but also cooperate with
domestic famous factories, colleges and universities, and laboratories in the industry actively. In addition, our company
has a series of advanced production equipment such as the preparation, extraction, leaching, chromatography, concentration,
purification, and vacuum drying equipment of pure water, as well as high performance liquid chromatography (HPLC) and various
experimental analysis equipment. In order to ensure the quality of our delivery products, strict management procedure for production
is executed.
Our company's main products cover Huperzia Serrata Extract - Huperzine-A, Horse Chestnut Extract - Aescin, Polygonum Cuspidatum
Extract/Grape Skin Extract - Resveratrol, Butcher's Broom Extract - Ruscogenin, Phloretin, Okra Extract, Curcumin, Sinomenine Hydrochloride,
Berbamine Hydrochloride, Ginseng Extract - Ginsenoside, Evodiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcumin,
Xanthin, Zeaxanthin, Ursolic acid, Naringin and Neohesperidin series products, Luteolin, Nattokinase, Piperine, Paeoniflorin, Pjosphatidylserine.
Most of our products are sold to inland, Macao and Taiwan, Europe and America, Southeast Asia and other countries and regions, enjoy high
popularity in these places and become the preferred products of many pharmaceutical, food, health care products and cosmetics production
enterprises at home and abroad.
Packing and Shipping
Delivery time :Within 3~10 working days after receiving the confirmed payment
MOQ : 1KG
Net Weight : 25kgs/Drum
Gross Weight : 28kgs/Drum
Payment :T/T,paypal or Alibaba Payment,If you need other payment methods, please contact us.
Freight : The freight cost will charge according to the destination detailed quantity.
Storage : Stored in dry and cool place, keep away from strong light and heat.
Shelf Life :Two years when properly stored.OUR SERVICE
1. We inspect the manufacture process strictly and the quality can be controlled.
2. We supply high quality products, reasonable price, prompt delivery.
3. Our products are natural,pure and no additives.
4. Free Sample To Test Quality First is Accepted.
5. Our products can be OEM,packaging can be done according to the yours requirements.
6. After SalServices 24*7.FAQ:
1.What's the min order for the usual?
15kg. As for the high-value products, min order starts from 1g or 10g.
2.What's the sample cost?
Free samples for normal products. Will charge on high-value products like huperzine-A.
3.What's the package and payment terms?
We pack with 2 layers of food-grade plastic bags inside and aluminum foil bag outside, 10-25kg/drum.And payment terms are normally T/T & Western Union.
4.What's the shipping time?
May take 3-5 working days to Asia or surrounding countries by EMS etc..
5~10 working days to European or Americ countries by EMS etc..
5.How do we do if the goods doesnt match with the sample?
Usually we'll confirm the testing method, if it is because of the quality, we''ll recalled the unquality goods and send free the products to you again. Please don't worry, our products were tested before the shipping.
Address:
a 2006, Yikongjian Huaxia, Gaoxin 5th Road, China. (721006), Baoji, Shaanxi, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals
Management System Certification:
ISO 9001
Company Introduction:
Baoji Runyu Bio-Technology Co., Ltd. Specialized in active ingredients from natural plant extracts and herbal extract, as well as in food additives, fruit powder and health care products more than 15 years in China.
We have long-term relationship with several Third-party Testing organizations to ensure high quality.
Our company′s main products cover Huperzia Serrata Extract - Huperzine-A, Horse Chestnut Extract - Aescin, Polygonum Cuspidatum Extract/Grape Skin Extract - Resveratrol, Butcher′s Broom Extract - Ruscogenin, Phloretin, Okra Extract, Curcumin, Sinomenine Hydrochloride, Berbamine Hydrochloride, Ginseng Extract - Ginsenoside, Evodiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcumin, Xanthin, Zeaxanthin, Ursolic acid, Naringin and Neohesperidin series products, Luteolin, Nattokinase, Piperine, Paeoniflorin, Pjosphatidylserine. Most of our products are sold to inland, Macao and Taiwan, Europe and America, Southeast Asia and other countries and regions, enjoy high popularity in these places and become the preferred products of food, health care products and cosmetics production enterprises at home and abroad.
With the concept of "Quality First, Customer Foremost, Sincere Management", we are devoting to build the quality brand. We are looking forward to communicating and cooperating with friends from all over the world. Let us work hand in hand to create a brilliant tomorrow.